The report, published on 6 February last year, accused the NHS system of betraying the public over the Stafford Hospital scandal.
The criticisms led to a series of changes, including a new inspection regime and tougher measures for failing hospitals.
Jeremy Hunt will say later these moves are making a difference.
'Shift in priorities'Addressing a health conference in London, he will also point to data from the Health and Social Care Information Centre from October 2013 - the latest available information - which shows the number of hospital nurses has been risen by more than 3,500 in the past 12 months to top 172,000.
Continue reading the main storyThe Francis Inquiry report made 290 recommendations. The government has claimed it has accepted all but nine of them.
Those not taken forward include the call for the regulators Monitor and the Care Quality Commission to be merged.
This was never likely to happen as both organisations had recently been given extra responsibilities and undergone changes under the reforms to the NHS made earlier this year.
But of the 281 recommendations the government says have been met, one in four have not been accepted in full.
For example, the report called for a system of registration for healthcare assistants, but the care certificate being introduced falls short of that.
Meanwhile, the inquiry wanted the duty of candour to apply to individuals not just organisations.
Nonetheless, inquiry chairman Robert Francis QC said he was happy, describing the government's response as a "comprehensive collection of measures".
Although data from the centre also shows that overall nurse numbers - once those employed outside of hospitals is taken into account - have fallen by more than 5,000 to just over 312,000 since the last election.Mr Hunt will say: "Twelve months on, we cannot expect to have solved everything or have completely transformed the culture of the country's largest and finest institution.
"But we have seen a real shift in priorities - new inspections, more nurses and a stronger voice for patients with compassionate care starting to replace tick-box targets as the major focus on boards and wards."
Since the report was published, 14 hospitals have been placed in special measures - with management either replaced or supported to make improvements.
A new post of chief inspector of hospitals has been created and the Care Quality Commission has overhauled the way it inspects hospitals.
This is leading to a new Ofsted-style rating system that will be rolled out later this year.
What is more, from April hospitals will have to publish staffing levels on wards and state whether they fall short of recommended numbers.
'Wrong direction'But Labour focused on the overall nurse figures, which had shown a drop.
Shadow health minister Jamie Reed said: "This winter he's left the NHS facing an A&E crisis with thousands fewer nurses. It is yet more proof that you can't trust the Tories with the NHS."
Royal College of Nursing general secretary Peter Carter said there had been some "good news".
But he added: "We are also not seeing nursing staff spread evenly across the health system - we have severe shortages in mental health and in the community, and district nurse numbers are down which is very worrying and has many knock-on effects.
"We need to see the government put forward a long-term vision for workforce planning and make sure NHS patients get the care they deserve wherever they receive it."
The inquiry was chaired by Robert Francis QC, following events at Stafford Hospital.
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